Full Name  Ann Wheeler
Phone   0131 651 8500
Email This email address is being protected from spambots. You need JavaScript enabled to view it.
Address MRC Human Genetics Unit
IGMM
Crewe Road
Edinburgh
EH4 2XU
United Kingdom

 

Ann is a cell biologist and our University of Edinburgh ESRIC facility manager with expertise in advanced light microscopy in particular in Structured Illumination Microscopy (SIM) and Single Molecule Localisation Super-resolution microscopy (SMLM) as well as quantitative image analysis. Ann works with collaborators in the generation of new methods and methodologies for visualising structures by super-resolution. 

Ann Figure 2Spinning disk super-resolution (SDSI) -dSTORM and SIM images of the mitotic spindle, the spindle was visualised using β-tubulin antibodies published in 2013: http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0074604

 

Some relevant publications:

  • A Restricted Repertoire of De Novo Mutations in ITPR1 Cause Gillespie Syndrome with Evidence for Dominant Negative Effect Rainger, J., DDD Study, Van Heyningen, V., Marsh, J., Elmslie, F. & FitzPatrick, D. 21 Apr 2016 In : American Journal of Human Genetics.
  • Human β-D-3 Exacerbates MDA5 but Suppresses TLR3 Responses to the Viral Molecular Pattern Mimic Polyinosinic:Polycytidylic Acid. Semple, F., MacPherson, H., Webb, S., Kilanowski, F., Lettice, L., McGlasson, S. L., Wheeler, A. P., Chen, V., Millhauser, G. L., Melrose, L., Davidson, D. J. & Dorin, J. R. 8 Dec 2015 In : PLoS Genetics. 11, 12, p. e1005673
  • The evolution of Structured Illumination Microscopy in studies of HIV, Marno, K., Al'Zoubi, L., Pearson, M., Posch, M., McKnight, Á. & Wheeler, A. 10 Jun 2015 In : Methods.
  • Synthesis and structure of free-standing germanium quantum dots and their application in live cell imaging. Karatutlu, A., Song, M., Wheeler, A. P., Ersoy, O., Little, W. R., Zhang, Y., Puech, P., Boi, F. S., Luklinska, Z. & Sapelkin, A. V. 13 Feb 2015 In : RSC Advances. 5, 26, p. 20566-20573 8 p.
  • Toll-like receptor 9 protects non-immune cells from stress by modulating mitochondrial ATP synthesis through the inhibition of SERCA2. Shintani, Y., Drexler, H. C. A., Kioka, H., Terracciano, C. M. N., Coppen, S. R., Imamura, H., Akao, M., Nakai, J., Wheeler, A. P., Higo, S., Nakayama, H., Takashima, S., Yashiro, K. & Suzuki, K. Apr 2014 In : EMBO Reports. 15, 4, p. 438-45 8 p.
  • Class II phosphoinositide 3-kinases contribute to endothelial cells morphogenesis. Tibolla, G., Piñeiro, R., Chiozzotto, D., Mavrommati, I., Wheeler, A. P., Norata, G. D., Catapano, A. L., Maffucci, T. & Falasca, M. 2013 In : PLoS One. 8, 1, p. e53808
  • P2X7 purinoceptors contribute to the death of Schwann cells transplanted into the spinal cord Luo, J., Lee, S., Wu, D., Yeh, J., Ellamushi, H., Wheeler, A. P., Warnes, G., Zhang, Y. & Bo, X. 2013 In : Cell Death and Disease. 4, p. e829
  • Super-resolution imaging strategies for cell biologists using a spinning disk microscope. Hosny, N. A., Song, M., Connelly, J. T., Ameer-Beg, S., Knight, M. M. & Wheeler, A. P. 2013 In : PLoS One. 8, 10, p. e74604
  • Desmoglein 3 acting as an upstream regulator of Rho GTPases, Rac-1/Cdc42 in the regulation of actin organisation and dynamics. Tsang, S. M., Brown, L., Gadmor, H., Gammon, L., Fortune, F., Wheeler, A. & Wan, H. 1 Nov 2012 In : Experimental Cell Research. 318, 18, p. 2269-83 15 p.
  • ROCK1 and ROCK2 regulate epithelial polarisation and geometric cell shape. Kalaji, R., Wheeler, A. P., Erasmus, J. C., Lee, S. Y., Endres, R. G., Cramer, L. P. & Braga, V. M. M. Aug 2012 In : Biology of the Cell. 104, 8, p. 435-51 17 p.
  • A novel regulatory mechanism links PLCγ1 to PDK1. Raimondi, C., Chikh, A., Wheeler, A. P., Maffucci, T. & Falasca, M. 1 Jul 2012 In : Journal of Cell Science. 125, Pt 13, p. 3153-63 11 p.
  • Characterizing the phenotype of murine epidermal progenitor cells: complementary whole-mount visualization and flow cytometry strategies. Henseleit, K. D., Wheeler, A. P., Warnes, G. & Braun, K. M. 2012 In : Methods in Molecular Biology. 916, p. 243-61 19 p.