|Full Name||Wendy Bickmore|
|Phone||0131 651 8800|
MRC Human Genetics Unit
Professor Wendy Bickmore is the Director of the MRC Human Genetics Unit at the Institute of Genetics and Molecular Medicine, Edinburgh University and an ESRIC PI. She is fascinated by the structure and organization of chromosomes in the nucleus and showed that different human chromosomes have preferred positions in the nucleus, addressed how genes are organized and packaged in the nucleus and how they move in the cell cycle and during development. Current research in Wendy Bickmore’s laboratory focuses on how the spatial organization of the nucleus influences genome function in development and disease and how epigenetic mechanisms impact on spatial chromatin conformation. Her group are expert in fluorescence in situ hybridization (FISH), analysed by wide-field deconvolution, confocal, and super-resolution microscopy – especially structured illumination microscopy (SIM).
Some relevant publications:
- Pradeepa MM, Grimes GR, Kumar Y, Olley G, Taylor GCA, Schneider R, Bickmore WA. (2016) Histone H3 globular domain acetylation identifies novel enhancers. Nature. Genet. 48:681-686.
- Illingworth RS, Moffat M, Mann AR, Read D, Hunter CJ, Pradeepa MM, Adams IR*, Bickmore WA*. (2015) The E3 ubiquitin ligase activity of RING1B is not essential for early mouse development. Genes. Dev. 29: 1897-1902. *Co-corresponding authors.
- Rafique S, Thomas SJ, Sproul D, Bickmore WA. (2015) Estrogen-induced chromatin decondensation and nuclear re- organisation linked to Regional Epigenetic Regulation in Breast Cancer. Genome Biol. 16: 145.
- Williamson I, Berlivet S, Eskeland R, Boyle S, llingworth RS, Paquette D, Dostie J, Bickmore WA. (2014) Spatial genome organisation: contrasting views from chromosome conformation capture and fluorescence in situ hybridisation. Genes. Dev. 28:2778-2791.
- Therizols P, Illingworth RS, Courilleau C, Boyle S, Wood AJ, Bickmore WA. (2014) Chromatin decondensation is sufficient to alter nuclear re-organization in embryonic stem cells. Science 346:1238-1242.
- Nolen LD, Boyle S, Ansari M, Pritchard E, Bickmore WA. (2013) Regional chromatin decompaction in Cornelia de Lange syndrome associated with NIPBL disruption can be uncoupled from cohesion and CTCF. Hum Mol. Genet 22: 4180-4193.
- Patel NS, Rhinn M, Halley PA, Dolle P, Bickmore WA*, Storey KG*. (2013) FGF signalling regulates chromatin organisation during neural differentiation via mechanism(s) that can be uncoupled from transcription. PLoS Genetics. 9:e1003614. *co-corresponding author.
- Kind J, Pagie L, Ortabozkoyun H, Boyle S, de Vries SA, Jansenn H, Amendola M, Nolen L, Bickmore WA, van Steensel B.. (2013) Single-cell dynamics of genome-lamina interactions. Cell 153:178-192.
- Boyle S, Rodesch M, Jeddeloh J, Bickmore WA. (2011) Sequence capture oligonucleotide pools as repeat-free probe sets for fluorescence in situ hybridization. Chrom. Res. 19:901-909.
- Eskeland R, Leeb M, Grimes G, Kress C, Boyle S, Sproul D, Gilbert N, Fan Y, Skoultchi AI, Wutz A, Bickmore WA. (2010) Ring1B compact chromatin structure and represses gene expression independent of histone ubiquitination. Mol Cell. 38: 452-464.